Urticarial vasculitis
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Sa 2022 na mga resulta ng Stiftung Warentest mula sa Germany, ang kasiyahan ng consumer sa ModelDerm ay bahagyang mas mababa kaysa sa mga bayad na konsultasyon sa telemedicine.
relevance score : -100.0%
ReferencesAng Urticarial vasculitis ay isang bihirang kondisyon na minamarkahan ng pangmatagalang o paulit-ulit na mga yugto ng pantal. Bagama't ang mga sintomas nito sa balat ay maaaring magmukhang katulad ng mga talamak na pantal, natatangi ang mga ito dahil nananatili ang pantal nang hindi bababa sa 24 na oras at maaaring mag-iwan ng madidilim na pekas pagkatapos mawala. Bagama't madalas hindi alam ang sanhi, maaari itong ma‑trigger ng ilang partikular na gamot, impeksyon, autoimmune disease, mga sakit sa dugo, o kanser. Iniugnay din ito ng ilang pag-aaral sa trangkaso ng COVID‑19 at H1N1. Maaari rin itong makaapekto sa iba pang bahagi ng katawan tulad ng mga kalamnan, bato, baga, tiyan, at mata. Bagama't maaaring kumpirmahin ang diagnosis sa pamamagitan ng tiyak na uri ng pagsusuri sa tissue, hindi ito palaging kinakailangan. Karaniwang nagsisimula ang paggamot sa mga antibiotic, dapsone, colchicine, o hydroxychloroquine para sa mas banayad na mga kaso. Para sa mas malalang kaso, maaaring kailanganin ang mga gamot na pumipigil sa immune system tulad ng methotrexate o corticosteroids. Kamakailan, ang mga biologic na therapy (rituximab, omalizumab, interleukin-1 inhibitors) ay nagpakita ng pangako para sa mga mahihirap na kaso.
Urticarial vasculitis is a rare clinicopathologic entity that is characterized by chronic or recurrent episodes of urticarial lesions. Skin findings of this disease can be difficult to distinguish visually from those of chronic idiopathic urticaria but are unique in that individual lesions persist for ≥24 hours and can leave behind dusky hyperpigmentation. This disease is most often idiopathic but has been linked to certain drugs, infections, autoimmune connective disease, myelodysplastic disorders, and malignancies. More recently, some authors have reported associations between urticarial vasculitis and COVID-19, as well as influenza A/H1N1 infection. Urticarial vasculitis can extend systemically as well, most often affecting the musculoskeletal, renal, pulmonary, gastrointestinal, and ocular systems. Features of leukocytoclastic vasculitis seen on histopathologic examination are diagnostic of this disease, but not always seen. In practice, antibiotics, dapsone, colchicine, and hydroxychloroquine are popular first-line therapies, especially for mild cutaneous disease. In more severe cases, immunosuppressives, including methotrexate, mycophenolate mofetil, azathioprine, and cyclosporine, as well as corticosteroids, may be necessary for control. More recently, select biologic therapies, including rituximab, omalizumab, and interleukin-1 inhibitors have shown promise for the treatment of recalcitrant or refractory cases.
Urticarial vasculitis is a rare clinicopathologic entity that is characterized by chronic or recurrent episodes of urticarial lesions. Skin findings of this disease can be difficult to distinguish visually from those of chronic idiopathic urticaria but are unique in that individual lesions persist for ≥24 hours and can leave behind dusky hyperpigmentation. This disease is most often idiopathic but has been linked to certain drugs, infections, autoimmune connective disease, myelodysplastic disorders, and malignancies. More recently, some authors have reported associations between urticarial vasculitis and COVID-19, as well as influenza A/H1N1 infection. Urticarial vasculitis can extend systemically as well, most often affecting the musculoskeletal, renal, pulmonary, gastrointestinal, and ocular systems. Features of leukocytoclastic vasculitis seen on histopathologic examination are diagnostic of this disease, but not always seen. In practice, antibiotics, dapsone, colchicine, and hydroxychloroquine are popular first-line therapies, especially for mild cutaneous disease. In more severe cases, immunosuppressives, including methotrexate, mycophenolate mofetil, azathioprine, and cyclosporine, as well as corticosteroids, may be necessary for control. More recently, select biologic therapies, including rituximab, omalizumab, and interleukin-1 inhibitors have shown promise for the treatment of recalcitrant or refractory cases.
Isang 35-taong-gulang na lalaki ang nagpunta dahil may 15-araw na kasaysayan ng matingkad na pulang, masakit na pantal sa magkabilang hita at binti, kasama ang pananakit ng mga kasukasuan. Nagkaroon siya ng impeksyon sa ihi isang linggo bago lumitaw ang mga pantal. Sa balat niya, nakita ang ilang malambot, hugis singsing, bahagyang namumulaklak, mapupulang plaka sa magkabilang gilid ng hita at binti. Binigyan siya ng oral prednisolone (40mg/araw) sa loob ng isang linggo kasama ang hindi nakakaantok na antihistamine na fexofenadine. Sa loob ng isang linggo, ganap na nawala ang lahat ng pantal. Wala nang pantal sa susunod na anim na buwan ng regular na follow‑up.
A 35-year-old man came in with a 15-day history of bright red, painful rashes on both thighs and legs, along with joint pain. He had a urinary tract infection for a week before the rash appeared. His skin showed several tender, ring-shaped, partially blanchable, red plaques on both sides of his thighs and legs. He was given oral prednisolone (40mg/day) for a week along with a non-drowsy antihistamine (fexofenadine). Within a week, all the rashes disappeared completely. There were no more rashes during the next 6 months of regular check-ups.
A 35-year-old man came in with a 15-day history of bright red, painful rashes on both thighs and legs, along with joint pain. He had a urinary tract infection for a week before the rash appeared. His skin showed several tender, ring-shaped, partially blanchable, red plaques on both sides of his thighs and legs. He was given oral prednisolone (40mg/day) for a week along with a non-drowsy antihistamine (fexofenadine). Within a week, all the rashes disappeared completely. There were no more rashes during the next 6 months of regular check-ups.
○ Paggamot ― OTC na Gamot
Kung mayroon kang lagnat (tumaas na temperatura ng katawan), inirerekomenda naming humingi ka ng medikal na atensyon sa lalong madaling panahon.
Dapat ihinto ang pinaghihinalaang gamot (hal. antibiotics, non‑steroidal anti‑inflammatory drugs).
Uminom ng oral antihistamines tulad ng cetirizine o loratadine para sa pangangati.
#Cetirizine [Zytec]
#LevoCetirizine [Xyzal]
#Loratadine [Claritin]
Ang mga OTC steroid ointment ay maaaring hindi epektibo kung mababa ang potency. Kailangan mag‑apply ng higit sa isang linggo upang makita ang pagbuti.
#Hydrocortisone ointment